Stewart, Bernal, et al. Compendium of Continuing Education in Dentistry (15488578) 46 (2025).
A major goal of plaque-control toothbrushing is the ability to control plaque in hard-to-brush areas, in particular interproximal plaque. Zinc lactate was evaluated as a formulation adjunct to a CPC mouthwash to determine whether the addition of zinc lactate as a formulation adjunct provides superior in-vivo control of established dental plaque and gingivitis versus CPC alone and versus placebo.
Experiments: A 6-week, randomized, examiner-blind, parallel-group clinical study of 116 subjects compared the efficacy of three alcohol-free mouthwashes: (1) Test Formula: 0.075% CPC, 0.28% Zinc Lactate, 0.05% sodium fluoride (CPC + Zn); (2) Active Control: 0.075% CPC, 0.05% sodium fluoride (CPC-only); (3) Placebo Control: A fluoride-free, alcohol-free placebo.
Key Results:
· The CPC + Zn and CPC-only formulas both had significantly greater plaque and gingivitis reduction than placebo in all plaque and gingivitis parameters at both 4 and 6 weeks.
· CPC + Zn versus CPC (after 6 weeks): the CPC + Zn test product delivered significantly greater reductions than CPC-only in each index (p<0.05): 16.1% greater reduction of whole-mouth plaque index; 16.4% greater reduction of interproximal plaque; 9.4% greater reduction of gumline plaque; 27.0% greater reduction of plaque severity; 13.2% greater reduction of whole-mouth gingival index; 14.8% greater reduction of interproximal gingivitis; 28.6% greater reduction of gingival bleeding.
Amrouche, Tahar, et al. Probiotics and antimicrobial proteins 2.4 (2010): 250-257.