Tetrabutylammonium fluoride

Catalog NumberHG429414

CAS Number429-41-4

CategoryCationic Surfactants

Synonyms

1-Butanaminium, N,N,N-tributyl-, fluoride (1:1)

Molecular Weight

261.46

Molecular Formula

C16H36FN

Appearance

Solid

Application

Use as antistatic agent.; Use as phase transfer catalyst.; Use as emulsifying agent, dispersing agent.

Active Content

95%

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Case Study

Tetrabutylammonium Fluoride as a Fluorine Source for Electrochemical and Radiofluorination of Methyl(Phenylthio)acetate

Balandeh, Mehrdad, et al. Journal of the Electrochemical Society 164.9 (2017): G99-G103.

Tetrabutylammonium fluoride (TBAF) serves as the fluoride source for the electrochemical fluorination and radiofluorination of methyl(phenylthio)acetate under controlled potential conditions.
Experimental Protocol: The electrolysis is performed in an undivided cell containing acetonitrile with 154 mM TBAF, 104.6 mM trifluoromethanesulfonic acid, and 25 mM substrate. A constant anodic potential of 1.4 V versus Ag/Ag⁺ is applied. The reaction temperature is maintained at 60 °C, and the electrolysis proceeds for 30 minutes.
Performance Evaluation: The monofluorinated product is obtained with a yield of 44 +/- 3% under the optimized conditions. Radiofluorination achieves an efficiency of 7 +/- 1%. The use of TBAF as the fluoride source provides a direct and efficient route for introducing fluorine into organic molecules, eliminating the need for pre-activated fluorinating agents. The electrochemical approach enables precise control over the reaction potential, minimizing side reactions and improving product selectivity.

Tetrabutylammonium Fluoride as a Cosolubilizer for Dispersing Noble Metal Nanoparticles in Aqueous Solution

Machida, Hironobu, et al. Journal of Crystal Growth 514 (2019): 14-20.

Tetrabutylammonium fluoride (TBAF) acts as a cosolubilizer in the preparation of stable aqueous dispersions of noble metal nanoparticles, including silver, palladium, iridium, and gold.
Experimental Protocol: Metal carboxylate precursors are mixed with TBAF and a thiol-based stabilizer at a molar ratio of Ag:F:TBA-3-MP = 1:10:2000. The mixtures are exposed to scattered sunlight and fluorescent light for one day at room temperature. The resulting nanoparticle dispersions are characterized by scanning transmission electron microscopy (STEM) for size distribution analysis.
Performance Evaluation: STEM observations reveal that the majority of nanoparticles are smaller than 10 nm in diameter across all four metal systems. The addition of TBAF significantly reduces the overall particle size compared to systems without TBAF. TBAF improves the solubility of silver carboxylate precursors in the aqueous medium, enabling more homogeneous nucleation and growth. The resulting nanoparticles remain well-dispersed without observable aggregation.

Tetrabutylammonium Fluoride as a Catalyst for Interlayer Silylation of Layered Octosilicate with Organotriethoxysilanes

Yatomi, Masashi, et al. European Journal of Inorganic Chemistry 2021.19 (2021): 1836-1845.

Tetrabutylammonium fluoride (TBAF) serves as an effective catalyst for the interlayer silylation of cetyltrimethylammonium (C16TMA)-exchanged layered octosilicate with organotriethoxysilanes.
Experimental Protocol: C16TMA-octosilicate is reacted with various organotriethoxysilanes, including octyltriethoxysilane (C8TES), octadecyltriethoxysilane (C18TES), and 3-mercaptopropyltriethoxysilane (MPTES). TBAF is added at a molar ratio of 0.27 relative to the reaction sites. The silylation reaction is carried out under controlled conditions, and the degree of silylation is determined by thermogravimetric analysis and solid-state NMR spectroscopy.
Performance Evaluation: The addition of TBAF significantly enhances the silylation extent across all silane reagents. For C8TES, the silylation degree increases from 33% (without TBAF) to 60% (with TBAF). For C18TES, the silylation degree improves from 23% to 68%. MPTES achieves the highest silylation degree of 89% in the presence of TBAF. TBAF catalyzes the hydrolysis and condensation of silane molecules within the confined interlayer space of the layered silicate.

• Synonyms: 1-Butanaminium, N,N,N-tributyl-, fluoride (1:1)
• Molecular Weight: 261.46
• Molecular Formula: C16H36FN
• Appearance: Solid
• Application: Use as antistatic agent.; Use as phase transfer catalyst.; Use as emulsifying agent, dispersing agent.
• Active Content: 95%