Sodium N-Lauroylglutamate

Catalog NumberHG29923317

CAS Number29923-31-7

CategoryAnionic Surfactants

Synonyms

L-Glutamic acid, N-(1-oxododecyl)-, sodium salt (1:1)

Molecular Weight

351.41

Molecular Formula

C17H30NNaO5

Appearance

Solid

Application

Use as emulsifying agent, dispersing agent.; Use as cleansing agent.; Use as wetting agent.

Active Content

85%

Download COA Download MSDS

Case Study

Counterion and NaCl Effects on the Surface Activity and Foaming of Sodium Lauroyl Glutamate Surfactants

Cao, Tianyu, et al. Colloids and Interfaces 9.6 (2025): 82.

Sodium lauroyl glutamate (SLG), a dicarboxylate amino-acid surfactant derived from glutamic acid, was compared with its potassium and ammonium salts to clarify how counterion identity and added NaCl regulate interfacial and foaming behaviour.
Experimental Protocol: Lauroyl glutamic acid was converted to SLG, PLG and ALG by reaction with equimolar sodium hydroxide, potassium hydroxide or ammonia in ethanol. Surface tension was measured at 25.0 °C and pH 7.00 plus or minus 0.05 in 10 mmol/L phosphate buffer, and cmc, minimum surface tension, surface excess and molecular area were derived from the Gibbs adsorption isotherm. Foam tests used a FoamScan instrument with 60 mL solution; nitrogen at 80 mL/min generated foam, the time to reach 150 mL defined foamability, and the residual foam volume at 1000 s defined foam stability. NaCl was added to SLG at 0, 1, 3 and 5 wt%.
Performance Evaluation: Counterions gave nearly identical surface activity: cmc was 2.46 x 10^-2 mol/L for SLG (surface tension 35.01 mN/m), 2.48 x 10^-2 mol/L for PLG (35.37 mN/m) and 2.36 x 10^-2 mol/L for ALG (35.01 mN/m). NaCl markedly lowered the cmc to 8.29 x 10^-3, 4.19 x 10^-3 and 2.79 x 10^-3 mol/L at 1%, 3% and 5% NaCl. 1% NaCl enhanced foam generation, while 3% NaCl produced the most stable foams; higher salt levels diminished foaming.

pH- and Temperature-Responsive Gel Formation Governs the Foam Stability of Sodium Lauroylglutamate

Zhang, Dianrui, et al. Colloids and Surfaces A: Physicochemical and Engineering Aspects 504 (2016): 384-392.

Sodium lauroylglutamate (LGS) is an amino-acid-based surfactant whose bulk aggregation, interfacial adsorption and foam characteristics respond to pH and temperature.
Experimental Protocol: A 0.7 wt% LGS solution (18.5 mM) was prepared and its pH adjusted with 1 M HCl; protonation was quantified by acid-base titration (25 mL of 0.05 M LGS titrated with 0.1 M HCl) and FTIR-ATR. Surface tension was measured with a du Nouy ring tensiometer at 25.0 °C. Gel strength was graded using a falling-ball method (weak tf below 10 s, moderate 10-600 s, strong at or above 600 s). Bulk and foam-film morphologies were examined by TEM and optical microscopy, and molecular behaviour at the gas/water interface by molecular dynamics simulation. Foam stability, expressed as half-time t1/2, was measured.
Performance Evaluation: The pKa1 and pKa2 of LGS were about 2.1 and 4.5, and the cmc at pH 10.0 was about 0.7 wt%. No gel formed above pH 5.0 or above 40 °C. When no gel formed, foam stability reached a maximum at pH about 7.0, where LGS molecules packed densely at the interface. At 20 °C and 30 °C, t1/2 rose sharply at pH 4.5 and pH 3.5 where weak gel formed, whereas strong gel (as at pH 3.0) destabilized the foam and caused rapid collapse.

Rapid Porcine Corneal Decellularization Using Sodium N-Lauroyl Glutamate and Supernuclease

Dong, Muchen, et al. Journal of Tissue Engineering 10 (2019): 2041731419875876.

Sodium N-lauroyl glutamate (SLG), a mild amino-acid-based detergent, was combined with supernuclease to develop a rapid decellularization method for porcine corneal stroma.
Experimental Protocol: Fresh porcine corneas from 4- to 6-month-old Duroc swine were cut into 500-um lamellae for in vitro work or 300-um lamellae (10 mm diameter) for animal work. Stroma was treated with 0.5% SLG, sodium N-lauroyl sarcosinate, sodium dodecyl sulfate or X-100, each supplemented with 200 U/mL supernuclease in PBS for 2 h at room temperature under shaking at 100 r/min. The SLG method (Method A, about 3 h) was compared with two traditional methods (B, more than 21 h; C, more than 43 h). Characterization used H&E and immunofluorescence staining, TEM, SEM, DNA, GAG and collagen assays and tensile testing; 300-um grafts were implanted in rabbits by lamellar keratoplasty.
Performance Evaluation: SLG plus supernuclease removed DNA from 78.90 plus or minus 1.48 to 1.02 plus or minus 0.07 ng/mg, more than 98% removal, versus 17.83 plus or minus 0.82 (SLS), 20.78 plus or minus 0.89 (SDS) and 34.57 plus or minus 1.25 ng/mg (Triton X-100). Moisture content was 91.80 plus or minus 0.37% and thickening rate 204.90 plus or minus 3.95%. Young modulus reached 10.63 plus or minus 0.54 MPa versus 3.89 plus or minus 0.30 MPa for native stroma. Grafts showed favorable transparency and no immune rejection at 1 month.

• Synonyms: L-Glutamic acid, N-(1-oxododecyl)-, sodium salt (1:1)
• Molecular Weight: 351.41
• Molecular Formula: C17H30NNaO5
• Appearance: Solid
• Application: Use as emulsifying agent, dispersing agent.; Use as cleansing agent.; Use as wetting agent.
• Active Content: 85%