Sodium Lauroyl Sarcosine

Catalog NumberHG137166

CAS Number137-16-6

CategoryAnionic Surfactants

Synonyms

Sodium lauroyl sarcosinate

Molecular Weight

293.38

Molecular Formula

C15H28NNaO3

Appearance

Solid

Application

Use as cleansing agent.; Use as dispersing agent, emulsifying agent.

Active Content

90%

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Case Study

Sodium Lauroyl Sarcosine as a Self-Assembling Surfactant for Micellar Aggregation Studies

Bajani, Deepnath, et al. Journal of colloid and interface science 529 (2018): 314-324.

Sodium lauroyl sarcosine (SLS) functions as an anionic surfactant for investigating self-assembly and micellar properties.
Experimental Protocol: Aqueous solutions of SLS and sodium lauroyl glycinate (SLG) are prepared at concentrations ranging from 0.1 to 20 mM. The critical micelle concentration (CMC) is determined by surface tension measurements and fluorescence spectroscopy using pyrene as a probe. Steady-state fluorescence anisotropy measurements are performed to evaluate microviscosity. All experiments are conducted at 25°C in phosphate buffer at pH 7.4.
Performance Evaluation: The CMC of SLS is determined to be 3.8 mM, while SLG exhibits a lower CMC of 2.6 mM, indicating that the glycinate headgroup promotes stronger micellar aggregation. The microviscosity of SLS micelles is 21 mPas, compared to 59 mPas for SLG micelles, suggesting that SLG forms more tightly packed micellar structures. These results demonstrate that headgroup chemistry significantly influences the aggregation behavior of amino acid-based surfactants.

Sodium Lauroyl Sarcosine as an Antibacterial Agent for Modified Clay Composites

Yapar, Saadet, et al. Applied Clay Science 150 (2017): 16-22.

Sodium lauroyl sarcosine (SLS) serves as an antibacterial agent when adsorbed onto cetylpyridinium-montmorillonite (CP-MMT) composites.
Experimental Protocol: CP-MMT is prepared by intercalating cetylpyridinium chloride into montmorillonite clay. SLS is then adsorbed onto CP-MMT at various loadings. The antibacterial activity is evaluated against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa using the minimum inhibitory concentration (MIC) assay. Bacterial cultures are incubated with the SLS-CP-MMT composites at 37°C for 24 h in nutrient broth.
Performance Evaluation: The SLS-adsorbed CP-MMT composite exhibits MIC values of 75 mg/mL against E. coli, 37.5 mg/mL against S. aureus, and 300 mg/mL against P. aeruginosa. The composite shows stronger activity against Gram-positive S. aureus than Gram-negative bacteria. The antibacterial efficacy is attributed to the synergistic effect of the cetylpyridinium cation and the SLS anion. This modified clay composite demonstrates potential for antimicrobial water treatment and surface disinfection applications.

Sodium Lauroyl Sarcosine as a Cleansing Agent for Facial Skin Microbiome and Lipidome Studies

Zhao, Huabing, et al. Journal of Cosmetic Dermatology 23.4 (2024): 1351-1359.

Sodium lauroyl sarcosine (SLS) functions as a cleansing surfactant for investigating its effects on the human facial skin microbiome and lipidome.
Experimental Protocol: A facial cleanser formulation containing 8% SLS is tested on 16 healthy volunteers over a 3-week period. Skin swab samples are collected before and after cleansing for 16S rRNA gene sequencing of bacterial communities. Skin lipid profiles are analyzed by liquid chromatography-mass spectrometry. Clinical assessments of skin barrier function are performed using transepidermal water loss measurements.
Performance Evaluation: SLS-based cleansing significantly decreases bacterial diversity on facial skin after 3 weeks of use. The lipidome analysis reveals increased phosphatidylglycerol (PG) and phosphatidylcholine (PC) levels, while ceramide levels are decreased. These lipid profile changes indicate that SLS alters the skin barrier composition. The study demonstrates that SLS-containing cleansers modulate both the microbial community and lipid composition of facial skin.

• Synonyms: Sodium lauroyl sarcosinate
• Molecular Weight: 293.38
• Molecular Formula: C15H28NNaO3
• Appearance: Solid
• Application: Use as cleansing agent.; Use as dispersing agent, emulsifying agent.
• Active Content: 90%