Sodium hexanoate

Catalog NumberHG10051442

CAS Number10051-44-2

CategoryAnionic Surfactants

Synonyms

Hexanoic acid, sodium salt

Molecular Weight

138.14

Molecular Formula

C6H11NaO2

Appearance

Solid

Application

Use as wetting agent, permeating agent.; Use as dispersing agent, emulsion stabilizer.; Use as hydrotrope.

Active Content

95%

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Case Study

Sodium Hexanoate as a Surfactant for Switchable Hydrophilicity Solvent Microextraction of Sudan Dyes from Solid Food Samples

Pochivalov, Aleksei, et al. Journal of Molecular Liquids 271 (2018): 807-814.

Sodium hexanoate functions as an anionic surfactant in a surfactant-mediated microextraction approach using switchable hydrophilicity solvent for the extraction of hydrophobic Sudan dyes from solid food samples.
Experimental Protocol: A 200 +/- 10 mg sample is mixed with 1 mL of 2.5 mol/L sodium hexanoate solution to form micelles. The mixture is placed in an ultrasonic thermostating bath (130 W, 35 kHz) at 60 °C for 20 minutes (salted salmon) or 70 °C for 10 minutes (spices). After cooling, 200 microL of 6 mol/L H₂SO₄ is added to protonate hexanoate ions, forming a hydrophobic hexanoic acid phase. The mixture is centrifuged at 3000 G for 10 minutes, and the organic phase is analyzed by HPLC-UV at 506 nm.
Performance Evaluation: The limits of detection are 0.19 mg/kg (Sudan I), 0.028 mg/kg (Sudan II), and 0.18 mg/kg (Sudan III). Recovery values range from 82% to 85% with relative standard deviations below 6%. The total sample pretreatment time is 25 minutes. The method consumes only 1 mL of extraction solvent, providing a greener alternative to conventional liquid-liquid extraction methods.

Sodium Hexanoate as an Emulsifier for Supramolecular Solvent Formation in Automated Dispersive Liquid-Liquid Microextraction of Polycyclic Aromatic Hydrocarbons

Timofeeva, Irina, et al. Talanta 224 (2021): 121888.

Sodium hexanoate acts as an emulsifier in a fully automated surfactant-assisted dispersive liquid-liquid microextraction (SA-DLLME) system for the preconcentration of 13 polycyclic aromatic hydrocarbons (PAHs) from tea infusion.
Experimental Protocol: A hydrophilic emulsion is prepared by mixing hexanoic acid and 1 mol/L NaOH at a 1:4 (v/v) ratio. In an in-syringe flow system, 3.8 mL of tea infusion sample and 1.2 mL of emulsion are aspirated into a 5 mL glass syringe and stirred magnetically for 10 seconds. After a 3-minute stop-flow period for spontaneous phase separation, 50 microL of the upper supramolecular solvent (SUPRAS) phase is collected and analyzed by HPLC with fluorescence detection.
Performance Evaluation: Enrichment factors range from 38 to 46 for the 13 PAHs. The SUPRAS phase consists of sodium hexanoate, water, and hexanoic acid in a molar ratio of 1:6:6. Limits of detection are 0.02-0.04 microg/L, and recovery values range from 85% to 105% with relative standard deviations below 4.1%. The linear detection range is 0.05-50.00 microg/L, and the total procedure time is less than 4 minutes.

Sodium Hexanoate as a Carbon Substrate for Adjustable Polyhydroxyalkanoate Copolymer Biosynthesis in Pseudomonas Putida

Tripathi, Lakshmi, et al. Bioresource technology 142 (2013): 225-231.

Sodium hexanoate serves as a structure-related carbon substrate for the biosynthesis of polyhydroxyalkanoates (PHA) with adjustable monomer compositions and block microstructures in beta-oxidation weakened Pseudomonas putida strains.
Experimental Protocol: P. putida KTOYO6DC (phaPCJAc) is cultivated on mixtures of sodium butyrate and sodium hexanoate (C4:C6) at varying ratios for random P(3HB-co-3HHx) copolymer production. P. putida KTQQ20 is grown on sodium hexanoate and decanoic acid (C6:C10) mixtures for P(3HHx-co-3HD) synthesis. For block copolymer production, hexanoate (4 g/L) is added at 0 hours, followed by dodecanoic acid (4 g/L) at 24 hours. Cultures are maintained in LB medium with 20 g/L glucose at 30 °C and 200 rpm for 48 hours.
Performance Evaluation: P(3HB-co-3HHx) copolymers achieve 3HHx contents adjustable from 19 mol% to 75 mol% with PHA content up to 61.46 wt% of cell dry weight. P(3HHx-co-3HD) copolymers exhibit 3HHx fractions from 16 mol% to 63 mol%. The block copolymer P3HHx-b-P(3HD-co-3HDD) shows a tensile strength of 15.91 MPa, elongation at break of 369.13%, and Young's modulus of 38.36 MPa, demonstrating superior mechanical properties.

• Synonyms: Hexanoic acid, sodium salt
• Molecular Weight: 138.14
• Molecular Formula: C6H11NaO2
• Appearance: Solid
• Application: Use as wetting agent, permeating agent.; Use as dispersing agent, emulsion stabilizer.; Use as hydrotrope.
• Active Content: 95%