Polyquaternium 22

Catalog NumberHG-RHE-M011

CAS Number53694-17-0

CategoryRheology Modifiers

Synonyms

Dimethyldiallylammonium chloride acrylic acid polymer

Appearance

Solid

Application

Used in hair care products such as relaxers, bleaches, shampoos, conditioners, dyes, and styling products.

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Case Study

Polyquaternium-22 as a Cosmetic Ingredient for Personal Care Product Safety

Johnson Jr, Wilbur, et al. International journal of toxicology 35.3_suppl (2016): 47S-53S.

Polyquaternium-22 (PQ22) serves as a cationic copolymer used in cosmetic formulations for its conditioning and film-forming properties.
Experimental Protocol: Safety assessment studies include acute oral toxicity testing in rats at doses up to 5 g/kg body weight, primary skin and eye irritation tests in rabbits, and skin sensitization assays using the guinea pig maximization test. Genotoxicity is evaluated via the Ames bacterial reverse mutation test and the in vitro mammalian chromosome aberration test. Clinical use concentrations range from 0.1 to 3% in leave-on and rinse-off products.
Performance Evaluation: The acute oral LD₅₀ of PQ22 exceeds 5 g/kg, indicating very low toxicity. The polymer is non-irritating to skin and minimally irritating to eyes in primary irritation tests. It is not a skin sensitizer in the guinea pig maximization test. Genotoxicity assays are negative for both bacterial and mammalian cell systems. Cosmetic formulations containing PQ22 at concentrations up to 2 to 3% demonstrate excellent safety profiles with no adverse effects reported in human repeat-insult patch tests. The polymer is considered safe for use in cosmetic products at current practice concentrations.

Polyquaternium-22 as a Membrane Surface Modifier for Anion-Exchange Membrane Antifouling

Butylskii, Dmitrii Y., et al. Membranes 12.11 (2022): 1065.

Polyquaternium-22 (PQ22) acts as a cationic polymer modifier that enhances the surface properties of commercial anion-exchange membranes for improved anti-scaling performance.
Experimental Protocol: Commercial anion-exchange membranes are immersed in a 2.5% aqueous solution of PQ22 for 8 hours at room temperature. Surface modification is characterized by contact angle measurements, streaming potential analysis, and atomic force microscopy. Electrochemical performance is evaluated using current-voltage curves and chronopotentiometry in a 0.02 M sodium chloride solution.
Performance Evaluation: PQ22 modification increases the surface charge density from 0.49 to 0.69 microcoulombs per cm², corresponding to a 40% enhancement. The limiting current density increases by approximately 1.5-fold after modification, from 32 to 48 A/m². Contact angle measurements show a decrease from 65 to 42 degrees, indicating improved hydrophilicity. Anti-scaling tests demonstrate a 60% reduction in calcium scale deposition on the modified membrane surface. The modified membrane maintains stable performance over 100 hours of continuous operation with less than 5% flux decline.

• Synonyms: Dimethyldiallylammonium chloride acrylic acid polymer
• Appearance: Solid
• Application: Used in hair care products such as relaxers, bleaches, shampoos, conditioners, dyes, and styling products.