Polyquaternium-6

Catalog NumberHG26062793

CAS Number26062-79-3

CategoryCationic Surfactants

Synonyms

N,N-Dimethyl-N-2-propenyl-2-propen-1-aminium chloride, homopolymer;Poly(dimethyl diallyl ammonium chloride);Poly-N,N-dimethyl-N,N-diallylammonium chloride;Poly(DMDAAC);2-Propen-1-aminium, N,N-dimethyl-N-2-propenyl-, chloride, homopolymer;Quaternium-40

Appearance

Liquid

Application

Use as antistatic agent.; Use as emulsifying agent, dispersing agent.; Use as flocculant.; Use as deodorant.; Use as film-forming agent.

Active Content

40%

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Case Study

Polyquaternium-6 as an Inflammatory Response Inducer for Aquatic Ecotoxicity Assessment

Hansen, Anna Magdalene Brun, et al. Journal of Hazardous Materials Letters 5 (2024): 100095.

Polyquaternium-6 (PQ6) acts as a cationic polymer that induces inflammatory responses and lipidome alterations in aquatic organisms.
Experimental Protocol: Zebrafish (Danio rerio) larvae are exposed to PQ6 at concentrations of 0.017, 0.05, 0.1, 0.2, and 0.4 mg/L for 96 hours. The polymer has a charge density of 6.2 mEq/g and a molecular weight of 29 kDa. Acute toxicity is determined via LC₅₀ calculation, and lipidomic analysis is performed using liquid chromatography-mass spectrometry. Inflammatory gene expression is quantified by real-time polymerase chain reaction.
Performance Evaluation: The 96-hour LC₅₀ value of PQ6 in zebrafish larvae is 0.91 mg/L. Exposure to 0.4 mg/L PQ6 significantly upregulates pro-inflammatory cytokine genes including interleukin-1 beta, tumor necrosis factor alpha, and interleukin-6 by 2.5 to 4.8-fold compared to controls. Lipidomic analysis reveals significant alterations in 47 lipid species, particularly glycerophospholipids and sphingolipids, indicating membrane disruption. The polymer induces a dose-dependent increase in reactive oxygen species production by up to 3.2-fold.

Polyquaternium-6 as a Hair Surface Modifier for Shampoo and Conditioner Formulations

Luengo, Gustavo S., et al. Surface science and adhesion in cosmetics (2021): 401-449.

Polyquaternium-6 (PQ6) functions as a cationic polyelectrolyte that modifies hair surface properties through electrostatic interactions with anionic surfactants.
Experimental Protocol: Binding isotherms of PQ6 with sodium dodecyl sulfate (SDS) and sodium lauryl ether sulfate (SLES) are constructed at varying molar ratios. The polymer-surfactant complexation is characterized using self-consistent field (SCF) modeling. Surface charge density and zeta potential measurements are conducted across a range of pH values from 4 to 8 and ionic strengths from 0.01 to 0.1 M.
Performance Evaluation: PQ6 forms stable electrostatic complexes with anionic surfactants at molar ratios between 1:1 and 1:3 (polymer to surfactant). The SCF model predicts that PQ6 adsorbs onto hair surfaces as a thin layer of 2 to 5 nm thickness, reducing the negative surface charge by 40 to 60%. The polymer-surfactant interaction is pH-dependent, with maximum binding occurring at pH 6 to 7. The complexation efficiency reaches 85 to 95% under optimal conditions, providing improved wet combing and reduced hair surface friction.

• Synonyms: N,N-Dimethyl-N-2-propenyl-2-propen-1-aminium chloride, homopolymer;Poly(dimethyl diallyl ammonium chloride);Poly-N,N-dimethyl-N,N-diallylammonium chloride;Poly(DMDAAC);2-Propen-1-aminium, N,N-dimethyl-N-2-propenyl-, chloride, homopolymer;Quaternium-40
• Appearance: Liquid
• Application: Use as antistatic agent.; Use as emulsifying agent, dispersing agent.; Use as flocculant.; Use as deodorant.; Use as film-forming agent.
• Active Content: 40%