Poly(N-isopropylacrylamide-co-methacrylic acid)

Catalog NumberHG-BULK151954971

CAS Number151954-97-1

CategoryPolymers

Molecular Weight

Mw ~16 - 190kDa

Appearance

White powder

Application

Precision Medicine: Tumor-targeted carriers for controlled release of chemotherapeutics; smart hydrogel patches for temperature-controlled antibiotic delivery.; Smart Materials: Flexible sensors (carbon nanotube composites) for monitoring body temperature/pH; self-healing coatings (repair efficiency >90%) for automotive and electronic protection.; Optical Technology: SERS-based biosensors for trace-level detection and analysis.

Storage

Keep in a cool, dark, and dry place

Composition Distribution

NIPAm : AA = 9 : 1

Specification

96% min

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Case Study

Poly(N-isopropylacrylamide-co-methacrylic acid) as pH/Thermo-Responsive Hydrogel for Self-Regulated Drug Delivery

Constantin, Marieta, et al. European Journal of Pharmaceutical Sciences 62 (2014): 86-95.

Poly(NIPAAm-co-MA) is a dual-responsive copolymer that loses thermosensitivity under physiological conditions (pH 7.4) due to ionized carboxyl groups. However, electrostatic interaction with positively charged hydrophobic drugs (e.g., propranolol) restores sharp phase transition near body temperature, enabling self-regulated drug release.
Fabrication Process: NIPAAm and MA were copolymerized (83.7/16.3 mol%) in PBS at pH 7.4. Porous microgels were synthesized by adding semitelechelic NIPAAm/HEAAm oligomers (porogen) during crosslinking with MBAAm at 22 °C (below copolymer LCST but above oligomer LCST). Non-porous microgels were prepared without porogen.
Performance Evaluation: In PBS at pH 7.4, the linear copolymer (16.7 mol% MA) showed no sharp LCST. After complexation with propranolol (1:1 drug/MA), LCST dropped to 33.4 °C. Porous microgels (exchange capacity 1.46 meq/g) exhibited faster swelling/collapsing kinetics than non-porous ones: collapsing half-time 82.5 min vs. 154 min; swelling half-time 9.3 min vs. 7.1 min (non-porous faster in swelling but porous overall more responsive). Propranolol absorption by porous microgels followed first-order kinetics, accompanied by rapid hydrogel shrinkage. The system acts as a self-regulated device: drug (triggering agent) binds carboxyl groups, restoring thermosensitivity and causing collapse to release payload.
Conclusion: Poly(NIPAAm-co-MA) hydrogels offer a smart platform for detecting biochemical triggers and delivering drugs in response to specific pathological signals.

• Molecular Weight: Mw ~16 - 190kDa
• Appearance: White powder
• Application: Precision Medicine: Tumor-targeted carriers for controlled release of chemotherapeutics; smart hydrogel patches for temperature-controlled antibiotic delivery.; Smart Materials: Flexible sensors (carbon nanotube composites) for monitoring body temperature/pH; self-healing coatings (repair efficiency >90%) for automotive and electronic protection.; Optical Technology: SERS-based biosensors for trace-level detection and analysis.
• Storage: Keep in a cool, dark, and dry place
• Composition Distribution: NIPAm : AA = 9 : 1
• Specification: 96% min