Methyl palmitate

Catalog NumberHG112390

CAS Number112-39-0

CategoryNon-ionic Surfactants

Synonyms

Hexadecanoic acid, methyl ester;Palmitic acid, methyl ester

Molecular Weight

270.45

Molecular Formula

C17H34O2

Appearance

Solid

Application

Use as dispersing agent, emulsion stabilizer.; Use as lubricant.; Use as intermediate in organic synthesis.

Active Content

95%

Download COA Download MSDS

Case Study

Methyl Palmitate Inhibits RAW Macrophage Activation and Bleomycin-Induced Lung Fibrosis via NF-kB Suppression

El-Demerdash, Ebtehal. Toxicology and applied pharmacology 254.3 (2011): 238-244.

Methyl palmitate (MP), the methyl ester of palmitic acid, was studied for its ability to inhibit macrophage activation and to prevent bleomycin-induced lung inflammation and fibrosis.
Experimental Protocol: RAW 264.7 murine macrophages of alveolar origin were treated with MP (purity >99%) at 0.25, 0.5 and 1.0 mM for 24 h; cytotoxicity was assessed by MTT assay, then cells were stimulated with 1 ug/ml Escherichia coli LPS for 6 h. Nitrite, IL-10, IL-6, TNF-a and IkBa phosphorylation at serine 32 were measured by Griess reagent and ELISA. Male albino rats (150-200 g) received bleomycin alone (15 mg/kg, i.p., three times per week for 4 weeks), bleomycin plus MP (300 mg/kg, i.p. on alternating days), MP alone, or vehicle, in four groups of six animals. Lung hydroxyproline and NF-kB p65 were quantified.
Performance Evaluation: Viability was 104%, 97% and 75% at 0.25, 0.5 and 1.0 mM. MP reduced phagocytosis to 77% (0.25 mM) and 65% (1.0 mM). LPS raised nitrite from 0.4 to 0.64 uM, while MP lowered it to 0.14 uM (0.25 mM) and 0.12 uM (0.5 mM), raised IL-10 three-fold and significantly reduced TNF-a at 0.5 mM. MP at 0.5 mM down-regulated IkBa phosphorylation. Bleomycin doubled hydroxyproline and induced NF-kB p65; MP co-treatment significantly ameliorated both effects.

Methyl Palmitate from Fermentation Broth Controls Meloidogyne incognita on Banana by Repelling Juveniles and Silencing Mi-flp-18 and 16D10

Lu, Qiaofang, et al. Journal of agricultural and food chemistry 68.24 (2020): 6502-6510.

Methyl palmitate was identified, together with methyl stearate, as a bioactive nematicidal compound in a fermentation broth of chicken manure and cassava ethanol wastewater evaluated against the root-knot nematode Meloidogyne incognita on banana.
Experimental Protocol: The broth (chicken manure to cassava ethanol wastewater 1:3; mixture to water 4:5) was fermented 45 days at 25-35 °C, filtered and diluted to 2-20%. Extracts were analysed by GC-MS, giving methyl palmitate at 10.58 min and methyl stearate at 11.64 min. Methyl palmitate and methyl stearate were dissolved in a Tween-80/dimethyl sulfoxide/acetone mixture (10/1/1, v/v/v) to 800 mM and diluted to 0.5-8.0 mM for egg-hatching assays; for chemotaxis, methanol solutions of 1.0-16.0 mM were placed on 1.0% agar plates with about 100 second-stage juveniles. Pot trials applied 0.5-8.0 mmol/kg to sterilized soil planted with banana seedlings.
Performance Evaluation: Control egg hatching was 36.8%; methyl palmitate inhibited hatching by 29.1-49.8% and methyl stearate by 57.7-95.5%. Chemotaxis indices of juveniles fell from -0.013 to -0.06 and from -0.0075 to -0.073. Methyl palmitate reduced root-knot numbers by 24.1-46.1%, egg masses by 37.4-56.5% and soil nematode density by 48.5-62.4%, and down-regulated Mi-flp-18 by more than 56.1% and 16D10 by more than 50%.

Palm Methyl Ester Additive Lowers Friction and Wear of Self-Mated SUS304 Steel at Boundary Lubrication

Fuadi, Z., et al. IOP Conference Series: Materials Science and Engineering. Vol. 796. No. 1. IOP Publishing, 2020.

Palm methyl ester, a bio-derived lubricant additive whose composition includes methyl palmitate, was investigated for its effect on the friction and wear of self-mated stainless steel SUS304 at boundary lubrication.
Experimental Protocol: Three lubricants were prepared by hand-shaking a commercial SAE40 oil with 0%, 0.5% and 1% palm methyl ester and designated PME0, PME5 and PME10. Friction tests used a ball-on-disk tribometer with a SUS304 ball (8 mm diameter, 4 mm thick) and disk, both hand-rubbed with #1000 sandpaper. Tests ran at a spindle revolution of 100 rpm, a sliding track diameter of 21 mm giving a sliding velocity of 0.0628 m/s, a sliding distance of 700 m, a 15 N normal load and an ambient temperature of 27 °C, producing an initial Hertzian contact pressure of 1.2 GPa. Palm methyl ester viscosity was 4.415 mm2/s at 40 °C, and worn surfaces were examined by 3D micrography.
Performance Evaluation: Average coefficient of friction was 0.7, 0.65 and 0.55 for PME0, PME5 and PME10, respectively. Adding 1% palm methyl ester reduced the coefficient of friction from 0.7 to 0.55, described as about a 10% reduction, and reduced the ball wear cross-section width from about 890 um (PME0) to 800 um (PME10), a 10% reduction. Darkening of the contact interfaces suggested an oxidative layer acting as a tribofilm.

• Synonyms: Hexadecanoic acid, methyl ester;Palmitic acid, methyl ester
• Molecular Weight: 270.45
• Molecular Formula: C17H34O2
• Appearance: Solid
• Application: Use as dispersing agent, emulsion stabilizer.; Use as lubricant.; Use as intermediate in organic synthesis.
• Active Content: 95%