Dimethiconol

Catalog NumberHG70131678

CAS Number70131-67-8

CategorySilicone Surfactants

Synonyms

Siloxanes and Silicones, di-Me, hydroxy-terminated;Poly(oxy(dimethylsilylene), alpha-hydro, omega-hydroxy-

Appearance

Liquid

Application

Use as film-formingagent.; Use as nonmetallic material.; Use as antifoaming agent

Active Content

30-100%

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Case Study

Clinical Evaluation of a Dimethiconol-Based Capillary Spray for the Treatment of Head Lice Infestation

Izri, A., et al. Parasite 17.4 (2010): 329-335.

Head lice infestation remains a widespread health concern. Growing resistance to chemical pesticides such as permethrin and increased safety concerns have accelerated the development of physical treatment alternatives. This study evaluated the efficacy and safety of a silicone-oil-based spray containing dimethiconol and castor oil for eradicating head lice and their eggs (nits).
Methodology: A prospective open cohort study was performed to assess the efficacy of a dimethiconol-castor oil spray in 108 infested patients (11 males, 97 females; 58 children, 50 adults). Subjects were treated with a single application of the dimethiconol-castor oil spray and the pediculicidal and ovicidal efficacy was determined. Pediculicidal efficacy was evaluated as the proportion of patients free of live lice one hour after treatment and on day 1 using wet-combing assessment. Ovicidal efficacy was determined as the proportion of subjects without viable nits or larval stages on days 1 and 7. A second application of the product was performed 7 days after the initial application in a subset of subjects.
Key Results:
· Pediculicidal Efficacy: One hour after treatment: 91.7% (99/108) of subjects were free of live lice. At day 1, 87% (86/99) remained free of live lice.
· Ovicidal Efficacy: At day 7, 73.2% (79/108) showed no evidence of larval development.
· Overall Cure Rate: After a second application (day 8), the cure rate increased to 79.6% (86/108).

Enhancing Bioactive Extraction in Cosmetic Formulations Using Dimethiconol-Based Silicone Systems

Saribekova, Diana, et al. Applied Sciences 11.22 (2021): 10625.

This study examined the application of dimethiconol, a key organosilicone ingredient, in improving the extraction of biologically active compounds from plant materials for use in cosmetic emulsions. The study highlighted the advantages of silicone-based extractants-particularly dimethiconol/cyclopentasiloxane blends-over traditional solvents like water and ethanol in preserving bioactivity and enhancing antioxidant performance.
Methods: Extractions were performed using Calendula Officinalis L. and Artemisia Absinthium L. with several silicone-based systems, including single-component silicones (e.g., polydimethylsiloxane, cyclopentasiloxane, phenyltrimethicone), multi-component systems, including a dimethiconol solution in cyclopentasiloxane and mixtures containing PEG-12 dimethicone and amodimethicone. Extraction efficiency was evaluated based on antioxidant activity with reference solution (activity value: 0.770).
Key Results:
· The dimethiconol/cyclopentasiloxane solution (BRB 1834) demonstrated high extraction efficacy, yielding antioxidant values of 1.507 for calendula and 1.111 for wormwood.
· These results significantly exceeded those of single-component silicones, which showed low antioxidant activity (0.204-0.457), and also surpassed aqueous extracts (calendula: 0.711; wormwood: 0.657).
· The presence of polar -OH groups in dimethiconol contributed to enhanced penetration through plant cell membranes and improved extraction efficiency.

• Synonyms: Siloxanes and Silicones, di-Me, hydroxy-terminated;Poly(oxy(dimethylsilylene), alpha-hydro, omega-hydroxy-
• Appearance: Liquid
• Application: Use as film-formingagent.; Use as nonmetallic material.; Use as antifoaming agent
• Active Content: 30-100%