Catalog NumberHG-RHE-M019
CategoryRheology Modifiers
Acrylates/C10-30 Alkyl Acrylate Crosspolymer for Synergistic Emulsification in O/W Emulsions
Kizeviciene, EDITA., et al. Acta Pol Pharm 74 (2017): 937-43.
Acrylates/C10-30 alkyl acrylate cross-polymer mixtures were evaluated as primary emulsifiers for preparing stable oil-in-water (o/w) pharmaceutical emulsions using olive oil. Emulsion stability depends critically on droplet size distribution, which was assessed via image analysis and converted to volume basis.
Experimental Protocol: Single polymers (PTR1 and PTR2) and their 1:1 mixture were tested at concentrations ranging from 0.02 to 0.4 wt% with olive oil loads of 10, 25, and 50 wt%. Emulsions were prepared at ambient temperature by dispersing the polymeric emulsifier in water containing sodium hydroxide (pH 6.0-6.5), followed by slow addition of oil under rotor-stator mixing at 800 rpm for 15 min. Droplet size was measured immediately after preparation and at 1, 2, 3, and 24 h using optical microscopy at 400× magnification. Surface and interfacial tensions were measured with a Du Noüy ring tensiometer. Statistical analysis employed two-way ANOVA with Tukey's multiple comparison tests (p < 0.05).
Performance Evaluation: The polymer mixture demonstrated a clear synergistic effect: the effective concentration of the PTR1/PTR2 mixture (0.04 wt% total) was substantially lower than that required for single polymers (0.15 wt% for PTR1 and 0.10 wt% for PTR2) at 50% oil loading. The mixture produced a significantly larger volume of small oil droplets (perimeter < 10 µm) and suppressed droplet coalescence over 24 h. Interfacial tension between the aqueous polymer mixture and olive oil was significantly lower (p < 0.05) compared to single polymers, indicating that reduced interfacial tension facilitated droplet breakup and stabilized the emulsion.
Acrylates/C10-30 Alkyl Acrylate Crosspolymer for Enhanced Dermal Penetration of Active Ingredients
Yamaga, Masayuki, et al. Journal of Dermatologic Science and Cosmetic Technology (2025): 100144.
Anionic cross-linked polymer formulations incorporating acrylates/C10-30 alkyl acrylate crosspolymer and carboxyvinyl polymer were investigated for enhancing dermal penetration of 10-hydroxy-2-decenoic acid (10H2DA), a low-molecular-weight unsaturated fatty acid from royal jelly with cosmetic and therapeutic potential.
Experimental Protocol: Seven cosmetic formulations with different polymers/polysaccharides were screened using Franz diffusion cells equipped with Strat-M artificial membranes. Formulation C, containing acrylates/C10-30 alkyl acrylate crosspolymer and carboxyvinyl polymer (each 0.23%), was compared against excipient-free royal jelly extract. Ex vivo validation employed trimmed human abdominal skin from two donors and full-thickness skin analyzed by DESI imaging mass spectrometry. A clinical tape-stripping study enrolled ten healthy women (aged 40-60 years) with high and low stratum corneum hydration levels. 10H2DA was quantified by LC-MS/MS.
Performance Evaluation: Formulation C increased 10H2DA permeation by more than tenfold (1060.9 ± 102.4 ng/cm² at 6 h) compared with the excipient-free control (107.3 ± 13.3 ng/cm²). DESI-IMS confirmed penetration into the epidermis beyond the stratum corneum. Mass balance analysis showed 3.6-5.4 times higher tissue transfer rate for formulation C. A strong positive correlation (r = 0.83, p < 0.05) was observed between SC hydration and 10H2DA penetration in the clinical study. The enhancement was attributed to electrostatic repulsion between anionic polymers and deprotonated 10H2DA, promoting passive diffusion toward the skin.