Sorbitan oleate

Catalog Number

HG1338438

CAS

1338-43-8

Structure

Synonyms

Span 80;Sorbitan esters, mono(Z)-9-octadecenoate;Sorbitan, mono-(9Z)-9-octadecenoate;Sorbitan, mono-9-octadecenoate, (Z)-;Sorbitan, monooleate;Sorbitan monooleate;Anhydrosorbitol monooleate

Molecular Weight

428.6

Molecular Formula

C24H44O6

Appearance

Liquid

Application

Use as lubricant.
Use as dispersing agent, emulsifying agent.
Use as plasticizer.

Active Content

95%

Case Study

Optimizing Mineral Agglomeration Selectivity with Sorbitan Monooleate

Schematic diagram of the mechanism of selective agglomeration of gangue using a combination of EDTA/Span 80. Sahasrabudhe, G., G. DeIuliis, et al. Colloids and Surfaces A: Physicochemical and Engineering Aspects 630 (2021): 127460.

Challenge: Enhancing selectivity in rapid mineral agglomeration processes using water-in-oil emulsions, where sorbitan monooleate (SMO) unintentionally hydrophobizes gangue particles, compromising target mineral recovery.
Solution: Investigating SMO's interaction mechanisms and implementing ethylene diamine tetraacetic acid (EDTA) pre-treatment to suppress gangue agglomeration.
Key Findings:
· Selectivity Limitation: SMO's sorbitan group interacts with transition metal ions adsorbed on gangue (e.g., silica/silicates), hydrophobizing and co-agglomerating non-target particles. This reduced selectivity occurred in model ores (chalcopyrite/silica, magnetite/silica) and industrial feeds (fine coal, chalcopyrite).
· EDTA Remediation: Pre-treating ores with EDTA removed adsorbed metal ions from gangue surfaces, preventing SMO interaction.
· Significant improvement in agglomeration selectivity for target minerals (rare earth oxides, PGMs, metal sulfides). The effectiveness of the EDTA solution was demonstrated across model systems and real industrial ore feeds. Supporting flotation studies further confirmed the role of SMO in the emulsion binder on selectivity.
· SMO demonstrated generic collector capability, hydrophobizing diverse transition/rare earth metal oxides and carbonates.

Enhancing Bio-Based Polyurethane Performance with Sorbitan Monooleate for UV Resistance, Corrosion Protection, and Toughness

Overview of high-performance bio-based waterborne polyurethanes prepared from sorbitan monooleate. Deng, Henghui, et al. Chemical Engineering Journal 446 (2022): 137124.

Sorbitan Monooleate (SP) was identified as a promising renewable polyol due to its unique molecular structure. It was strategically incorporated alongside castor oil to synthesize a novel series of bio-based WPU dispersions. The hydroxyl ratio between SP and castor oil was systematically optimized to tailor the final material properties.
Methodology: SP served as a key bio-derived building block in the WPU formulation, leveraging its distinct chemistry. The influence of SP/castor oil hydroxyl ratios on the chemical structure, dispersion stability, and resulting film properties was rigorously investigated.
Results & Performance:
· Unmatched Mechanical Strength: Films exhibited extraordinary toughness and thermo-physical properties, attributed to strong hydrogen bonding, the presence of rigid furan rings, and high crosslinking densities enabled by SP. Quantitatively, the films could lift objects 10,330 times their own weight.
· Superior UV Resistance: Coatings showed excellent resistance to ultraviolet radiation across the 200-400 nm spectrum. This performance was validated and maintained in real-world outdoor exposure tests.
· Effective Corrosion Protection: Applied as coatings on tinplate, the WPU provided significant anticorrosion effects. Outdoor testing demonstrated a protection period of at least 6 months, supported by electrochemical data: corrosion potential (-0.507 V), corrosion current (2.92 × 10-6 A), and a high corrosion protection efficiency (95.39%).

Enhancing Olanzapine Transdermal Delivery Efficiency with Sorbitan Monooleate

Schematic diagram of the mechanism of how sorbitan monooleate promotes the release of olanzapine from transdermal patches. Li, Ning, et al. European Journal of Pharmaceutical Sciences 107 (2017): 138-147.

Sorbitan Monooleate (SP) was investigated as a multifunctional enhancer in olanzapine (OLN) transdermal patches. A comprehensive molecular-level study was conducted to understand SP's dual-action mechanism in enhancing both drug release and skin absorption.
Methodology: OLN and SP were dispersed in ethyl acetate, mixed with pressure-sensitive adhesive (PSA), coated onto a release liner, dried (room temperature 10 min + 50°C oven 10 min), and laminated with polyester backing film. Patches were cut to 0.785 cm2 for testing. Rheological testing, DSC, FT-IR, and molecular modeling characterized SP's effect on PSA-drug interactions.
Key Findings:
· Enhanced Drug Release: SP weakened hydrogen bonding between OLN and PSA. This reduced cohesive polymer chain interactions and increased PSA free volume, significantly promoting OLN release from the adhesive matrix.
· Improved Skin Permeation: SP's O-H groups interacted with polar head groups of skin ceramides. This increased lipid fluidity within the stratum corneum, enhancing OLN's ability to penetrate the skin barrier.

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