Polyquaternium-37

Catalog Number

HG26161331

CAS

26161-33-1

Structure

Synonyms

Ethanaminium, N,N,N-trimethyl-2-((2-methyl-1-oxo-2-propenyl)oxy)-, chloride, homopolymer;N,N,N-Trimethyl-2-((2-methyl-1-oxo-2-propenyl)oxy)ethanaminium chloride, homopolymer

Appearance

Solid

Application

Use as antistatic agent.; Use as emulsifying agent, dispersing agent.; Use as flocculant.; Use as film-forming agent.; Use as thickening agent.

Active Content

90%

Case Study

Application of Polyquaternium-37 in Antiviral Alcohol-Based Hand Sanitizer Formulation

Macinga, David R., et al. Applied and environmental microbiology 74.16 (2008): 5047-5052.

Challenge: Traditional alcohol sanitizers failed to effectively inactivate non-enveloped enteric viruses (e.g., norovirus, rotavirus), posing transmission risks in food and healthcare settings.
Solution: Developed an optimized sanitizer formula (termed VF447) containing 70% ethanol + polyquaternium-37 (PQ-37) + citric acid + skin-conditioning agents for tolerability.
Key Findings:
· Ethanol alone (≤78%) showed minimal efficacy against the surrogate for nonenveloped mammalian viruses like bacteriophage MS2 (<1 log₁₀ reduction).
· PQ-37 significantly enhanced ethanol's potency (1.06 log₁₀ reduction vs. MS2; P<0.001).
· Synergy with citric acid: Combining PQ-37 + citric acid + ethanol achieved 4.36 log₁₀ reduction of MS2.
· In suspension tests (30-second exposure), VF447 reduced human rotavirus (HRV), poliovirus (PV-1), and norovirus surrogates (FCV, MNV-1) by >3 log₁₀.
· In fingerpad tests, VF447 reduced MNV-1 by 2.48 log₁₀, Reduced Infectious Titers of ADV-5 and HRV by ≥3.16 log₁₀ and ≥4.32 log₁₀.

Polyquaternium-37 - A Multifunctional Polymer Revolutionizing Cosmetic & Skincare Formulations

Musa, Osama M., et al. Polymers for personal care and cosmetics. American Chemical Society, 2013. 233-284.

Challenge: Conditioners, surfactants, or foam boosters can combine to provide conditioning, rheology, hold, and texture benefits without being too greey, restricted by pH, or processed. Formulators are seeking a universal all-in-one solution.
Solution: Polyquaternium-37 (PQ-37) delivers unprecedented versatility: homopolymer of trimethylaminoethyl methacrylate with high cationic charge density (≤4.2 meq/g); narrow-range molecular weight (400,000 Da) enables flexible hold and volume at low doses (0.1-3.0%).
Key Performance Advantages:
· Hair Care Superiority: At 0.5%, it can builds volume, sheen, and 7,000-13,000 cps viscosity. Eliminates greasiness while providing effortless detangling, dry-comb reduction, and flyaway control.
· Skin & Emulsion Innovation: Works as cationic emulsifier/softener in cream/lotion applications. Develops soft, waterproof film that is compatible with iron oxides, sunscreens, and self-tanning agents.
· Processing Efficiency: Self-thickening with no neutralization required.
· Flexible formats: 100% low-dust powder or pre-dispersed in mineral oil/propylene glycol dicaprylate.
· Ethanol-tolerant: Stable in systems containing ≤70% ethanol.
· pH Stability: Optimally performs at pH 3-7 (ester group degradation occurs above pH 7).

• Catalog Number: HG26161331
• CAS: 26161-33-1
• Synonyms: Ethanaminium, N,N,N-trimethyl-2-((2-methyl-1-oxo-2-propenyl)oxy)-, chloride, homopolymer;N,N,N-Trimethyl-2-((2-methyl-1-oxo-2-propenyl)oxy)ethanaminium chloride, homopolymer
• Appearance: Solid
• Application: Use as antistatic agent.; Use as emulsifying agent, dispersing agent.; Use as flocculant.; Use as film-forming agent.; Use as thickening agent.
• Active Content: 90%