Sodium Xylenesulfonate

Catalog Number

HG1300727

CAS

1300-72-7

Structure

Synonyms

Sodium Xylene Sulfonate

Molecular Weight

208.21

Molecular Formula

C8H9NaO3S

Appearance

Solid

Application

Use as hydrotrope.; Use as auxilialy emulsifying agent, auxilialy dispersing agent.

Active Content

90%

Case Study

Sodium Xylenesulfonate-Enabled High-Purity Lignin Extraction for Functional Biomaterials

Arunmas, Ekabhop, et al. Bioresource Technology (2025): 132988.

Challenge: The three major bottlenecks in conventional lignin extraction are inefficient lignin-carbohydrate separation, excessive solvent consumption and processing, and inevitable structural damages that impede bioactivity.
Solution: Sodium Xylenesulfonate (SXS) revolutionized accelerated solvent extraction (ASE) in this work by acting as a molecular scalpel selectively cleaving β-O-4 bonds, enabling high-purity extraction (97.61%) at low concentration (10% w/v), and preserving critical phenolic/carboxyl groups for enhanced functionality.
Optimized ASE-SXS Protocol: Load sugarcane bagasse into ASE reactor with 10% SXS solution, extract at 200°C for 3 hours, and recover syringyl-rich lignin with targeted Mw 2,100 Da.
Key Results:
· The SXS-extracted lignin showed significantly higher ABTS and DPPH scavenging values, achieving as high as 1,105.70 and 939.85 mg Trolox equivalent (TE)/g, respectively, which is 3.4× of magnitude higher than that of the conventionally prepared alkaline lignin.
· The SXS-extracted lignin also showed strong antibacterial efficacy, with the minimal inhibitory concentration (MICs) values ranging from 0.156 to 2.5 mg/mL.
· Furthermore, the SXS-extracted lignin also showed an improved selectivity, where it also maintained a better compatibility with probiotics. For example, SXS-extracted lignin was less toxic to Limosilactobacillus reuteri in comparison to alkaline lignin.

Increasing the Extraction Yield of Resveratrol Using Sodium Xylenesulfonate (SXS)

Dhayalan, Sreenivasan, et al. AIP Conference Proceedings. Vol. 2240. No. 1. AIP Publishing LLC, 2020.

Challenge: Resveratrol is an antibacterial and antifungal phytochemical that is difficult to extract and isolate due to low aqueous solubility and light sensitivity. Conventional extraction methods using organic solvents were low-yield and had stability issues.
Approach: A strong hydrotropic agent, sodium xylenesulfonate (SXS), was applied to dramatically improve the water solubility of resveratrol. SXS functions by non-micellar solubilization, which can further increase the solubility of surfactants in water.
Optimized Extraction Procedure: The extraction of resveratrol was performed using an ultrasound-assisted method in the dark to avoid photodegradation. Resveratrol was added to 50 mL solutions of SXS at different concentrations (0.2-0.8 M). Solubility was measured using UV-Vis spectroscopy (λmax = 306 nm). Concentration and purity of resveratrol was determined using HPLC.
Results:
· SXS allowed for a dramatic increase in the solubility of resveratrol, with the highest increase in solubility at high hydrotrope concentrations and high temperature. SXS was the best-performing hydrotrope out of those compared for solubilizing resveratrol.
· Application of this technology could be used to facilitate more sustainable, water-based extraction processes of resveratrol for high-purity delivery of bioactives in pharmaceutical, cosmetic, and functional food industries.

• Catalog Number: HG1300727
• CAS: 1300-72-7
• Synonyms: Sodium Xylene Sulfonate
• Molecular Weight: 208.21
• Molecular Formula: C8H9NaO3S
• Appearance: Solid
• Application: Use as hydrotrope.; Use as auxilialy emulsifying agent, auxilialy dispersing agent.
• Active Content: 90%