Cellulose, carboxymethyl ether

Catalog Number

HG9000117

CAS

9000-11-7

Structure

Synonyms

Carboxymethyl cellulose

Appearance

Solid

Application

Use as dispersing agent, emulsifying agent.; Use as thickening agent.; Use as film-forming agent.; Use as adhesive.; Use as sustained-release agent.

Active Content

85%

Case Study

Enhancing 3D Bioprinting Performance with Carboxymethyl Cellulose (CMC) in Hybrid Hydrogels

Habib, Ahasan, et al. Materials 11.3 (2018): 454.

Challenge: 3D bioprinting with pure natural hydrogels alone often suffers from inadequate mechanical strength and shape fidelity, resulting in poor stability and definition of the printed tissue scaffolds for more complex architecture.
Solution: This case study used carboxymethyl cellulose (CMC) as a potential additive to develop a hybrid hydrogel with improved printability, structural fidelity, and biological performance for 3D-bioprinted scaffolds.
Preparation Strategy: Alginate-CMC solutions were prepared in water and cross-linked instantly using 4% CaCl2 during extrusion-based printing. Alginate and CMC molecules are both negatively charged with carboxyl groups (-COO^-), which can undergo ionic crosslinking in the presence of calcium ions (Ca2+), allowing for rapid gelation.
Key Results:
· Printability and Shape Fidelity: The introduction of CMC into the hydrogel formulation resulted in improved layer stacking and better geometric accuracy of the printed scaffolds.
· Mechanical Integrity: The hybrid hydrogel was more resistant to deformation under stress and thus more appropriate to print complex and load-bearing tissue structures.
· Biocompatibility: Encapsulated pancreatic cancer cells (BxPC3) showed 86% viability after 23 days, confirming biocompatibility.

Carboxymethyl Cellulose as a Green Reducing and Stabilizing Agent for Silver Nanoparticles

Hebeish, A. A., et al. Carbohydrate polymers 82.3 (2010): 933-941.

Challenge: Common methods for making concentrated stable silver nanoparticles (AgNPs) involve toxic chemicals which cause environmental and safety issues and have been found difficult to scale, which is a concern for many applications (e.g., antimicrobial textiles) that require high concentrations of AgNPs.
Solution: Carboxymethyl Cellulose (CMC) was used as a green reducing agent (convert Ag+ ions to Ag0 metal) as well as a stabilizing agent for the formed AgNPs. Synthesis of AgNPs was achieved using CMC with a specific Degree of Substitution (DS, 1.22-2.2) and Degree of Polymerization (DP), and with specific other key parameters including a pH of 12.5, temperature of 70°C, a reaction time of 60 min, and ratio of 0.017g AgNO3:0.3g CMC in 100ml total solution. It was found that a higher DS provided a greater electrostatic stabilization effect.
Preparation Details: In the optimized synthesis method, a particular CMC with specific DP (~350) and DS (1.22) was dissolved in water, pH adjusted to 12.5, then heated to 70°C and stirred, followed by addition of AgNO3 solution dropwise; real time formation of the AgNPs was indicated by the color change of the solution to yellow and also confirmed by UV-Vis spectroscopy.
Key Findings: By using CMC, a very high AgNP concentration of 1000 ppm was achieved, with a 86% reduction efficiency. The particles are small (10-25 nm), with narrow size distribution and spherical shape, and have greater colloidal stability, particularly with higher DS CMC.

• Catalog Number: HG9000117
• CAS: 9000-11-7
• Synonyms: Carboxymethyl cellulose
• Appearance: Solid
• Application: Use as dispersing agent, emulsifying agent.; Use as thickening agent.; Use as film-forming agent.; Use as adhesive.; Use as sustained-release agent.
• Active Content: 85%